Aspects of cytomegalovirus reactivation in critically ill patients

Cytomegalovirus plays an essential role in human pathology. Primary infection usually occurs childhood and subsequently, a lifelong latency is formed which the virus replicates by evading immune response. In recent years, more researchers have concluded that cytomegalovirus reactivation may occur critically ill patients. Despite available evidence, data on this group of patients are limited relatively small sample size, variety patient groups studied, differences study methodology, variability reported results, excludes possibility summarizing results. This aimed to determine frequency identify its main clinical features. Materials methods. The included 118 with severe bacterial viral-bacterial infections accompanied multiple organ dysfunction. was determined detection DNA combination presence IgG. Results. Reactivation detected 36.4% cases. Frequency terms blood sputum as well trends viral load changes dynamics were shown. features different pathologies (sepsis etiology, COVID-19, non-septic critical patients) noted. HCMV frequently septic (44.8%) compared COVID-19 (13.0%, p<0.05) (19.2%, p<0.05). characterized not only lower but also lowest loads (p<0.05). comparably sepsis (38.1%) (33.3%), highest characteristic